Peer R. E. Mittl: search on Z-Library

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1

Evolution of a highly active and enantiospecific metalloenzyme from short peptides

Studer, Sabine, Hansen, Douglas A., Pianowski, Zbigniew L., Mittl, Peer R. E., Debon, Aaron, Guffy, Sharon L., Der, Bryan S., Kuhlman, Brian, Hilvert, Donald

Journal:

Year:

2018

Language:

english

File:

PDF, 569 KB

english, 2018

2

Drug design inspired by Nature: Crystallographic detection of auto-tailored protease inhibitor template

Gall, Flavio M., Hohl, Deborah, Frasson, David, Wermelinger, Tobias, Mittl, Peer R. E., Sievers, Martin, Riedl, Rainer

Journal:

Angewandte Chemie International Edition

Year:

2019

Language:

english

File:

PDF, 2.34 MB

english, 2019

3

Titelbild: Von der Natur inspiriertes Wirkstoffdesign: kristallographische Detektion eines selbstgenerierten Inhibitor‐Grundgerüsts (Angew. Chem. 12/2019)

Gall, Flavio M., Hohl, Deborah, Frasson, David, Wermelinger, Tobias, Mittl, Peer R. E., Sievers, Martin, Riedl, Rainer

Journal:

Angewandte Chemie

Year:

2019

File:

PDF, 413 KB

2019

4

Structure–Activity Studies in a Family of β-Hairpin Protein Epitope Mimetic Inhibitors of the p53–HDM2 Protein–Protein Interaction

Rudi Fasan, Ricardo L. A. Dias, Kerstin Moehle, Oliver Zerbe, Daniel Obrecht, Peer R. E. Mittl, Markus G. Grütter, John A. Robinson

Journal:

Year:

2006

Language:

english

File:

PDF, 1.10 MB

english, 2006

5

Selective and Sensitive Monitoring of Caspase-1 Activity by a Novel Bioluminescent Activity-Based Probe

Maik Kindermann, Heidi Roschitzki-Voser, Dejan Caglič, Urška Repnik, Catherine Miniejew, Peer R.E. Mittl, Gregor Kosec, Markus G. Grütter, Boris Turk, K. Ulrich Wendt

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 521 KB

english, 2010

6

Structural genomics: opportunities and challenges

Peer R.E Mittl, Markus G Grütter

Journal:

Current Opinion in Chemical Biology

Year:

2001

Language:

english

File:

PDF, 72 KB

english, 2001

7

Structure of glutathione reductase from escherichia coli at 1.86 Å resolution: Comparison with the enzyme from human erythrocytes

Peer R.E. Mittl, Georg E. Schulz

Journal:

Protein Science

Year:

1994

Language:

english

File:

PDF, 1.64 MB

english, 1994

8

The crystal structure of TGF-β3 and comparison to TGF-β2: Implications for receptor binding

Peer R. E. Mittl, John P. Priestle, David A. Cox, Gary Mcmaster, Nico Cerletti, Markus G. Grütter

Journal:

Protein Science

Year:

1996

Language:

english

File:

PDF, 5.58 MB

english, 1996

9

Monitoring the Disulfide Bond Formation of a Cysteine-Rich Repeat Protein fromHelicobacter pyloriin the Periplasm ofEscherichia coli

Venkataramani Sathya Devi, Peer R. E. Mittl

Journal:

Current Microbiology

Year:

2011

Language:

english

File:

PDF, 235 KB

english, 2011

10

Recognition of Host Proteins by Helicobacter Cysteine-Rich Protein C

Bernd Roschitzki, Stefan Schauer, Peer R. E. Mittl

Journal:

Current Microbiology

Year:

2011

Language:

english

File:

PDF, 940 KB

english, 2011

11

Identification of cylin-dependent kinase 1 inhibitors of a new chemical type by structure-based design and database searching

Pascal Furet, Thomas Meyer, Peer Mittl, Heinz Fretz

Journal:

Journal of Computer-Aided Molecular Design

Year:

2001

Language:

english

File:

PDF, 111 KB

english, 2001

12

Structure-based optimization of designed Armadillo-repeat proteins

Chaithanya Madhurantakam, Gautham Varadamsetty, Markus G. Grütter, Andreas Plückthun, Peer R.E. Mittl

Journal:

Protein Science

Year:

2012

Language:

english

File:

PDF, 1.35 MB

english, 2012

13

Sel1-like repeat proteins in signal transduction

Peer R.E. Mittl, Wulf Schneider-Brachert

Journal:

Cellular Signalling

Year:

2007

Language:

english

File:

PDF, 802 KB

english, 2007

14

The secreted Helicobacter cysteine-rich protein A causes adherence of human monocytes and differentiation into a macrophage-like phenotype

Claudia Dumrese, Lutz Slomianka, Urs Ziegler, Sung Sook Choi, Awdhesh Kalia, Alma Fulurija, Wei Lu, Douglas E. Berg, Mohammed Benghezal, Barry Marshall, Peer R.E. Mittl

Journal:

Year:

2009

Language:

english

File:

PDF, 429 KB

english, 2009

15

Opportunities for structure-based design of protease-directed drugs

Peer RE Mittl, Markus G Grütter

Journal:

Current Opinion in Structural Biology

Year:

2006

Language:

english

File:

PDF, 1012 KB

english, 2006

16

A new structural class of serine protease inhibitors revealed by the structure of the hirustasin–kallikrein complex

Peer RE Mittl, Stefania Di Marco, Gabriele Fendrich, Gabriele Pohlig, Jutta Heim, Christian Sommerhoff, Hans Fritz, John P Priestle, Markus G Grütter

Journal:

Year:

1997

Language:

english

File:

PDF, 767 KB

english, 1997

17

The 1.2 Å crystal structure of hirustasin reveals the intrinsic flexibility of a family of highly disulphide-bridged inhibitors

Isabel Usón, George M Sheldrick, Eric de La Fortelle, Gerard Bricogne, Stefania Di Marco, John P Priestle, Markus G Grütter, Peer RE Mittl

Journal:

Year:

1999

Language:

english

File:

PDF, 885 KB

english, 1999

18

The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis

Helen Blanchard, Lalitha Kodandapani, Peer RE Mittl, Stefania Di Marco, Joseph F Krebs, Joe C Wu, Kevin J Tomaselli, Markus G Grütter

Journal:

Year:

1999

Language:

english

File:

PDF, 485 KB

english, 1999

19

Identification of a Human cDNA Encoding a Kinase-Defective Cdk5 Isoform

Mark Moorthamer, Sabine Zumstein-Mecker, Christine Stephan, Peer Mittl, Bhabatosh Chaudhuri

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 322 KB

english, 1998

20

Structural Differences between Wild-type NADP-dependent Glutathione Reductase from Escherichia coli and a Redesigned NAD-dependent Mutant

Peer R.E. Mittl, Alan Berry, Nigel S. Scrutton, Richard N. Perham, Georg E. Schulz

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 269 KB

1993

21

In vitro structure-function analysis of the β-strand 326-333 of human p53

Patrick Chène, Peer Mittl, Markus Grütter

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 460 KB

english, 1997

22

Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex

Alain C Tissot, Carlo Ciatto, Peer R.E Mittl, Markus G Grütter, Andreas Plückthun

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 464 KB

english, 2000

23

Structure of the PRYSPRY-domain: Implications for autoinflammatory diseases

Christian Grütter, Christophe Briand, Guido Capitani, Peer R.E. Mittl, Stephanie Papin, Jürg Tschopp, Markus G. Grütter

Journal:

Year:

2006

Language:

english

File:

PDF, 1.65 MB

english, 2006

24

The Crystal Structure of Helicobacter Cysteine-rich Protein C at 2.0 Å Resolution: Similar Peptide-binding Sites in TPR and SEL1-like Repeat Proteins

Lucas Lüthy, Markus G Grütter, Peer R.E Mittl

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 587 KB

english, 2004

25

Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-ray Structure Analysis

Rajkumar Ganesan, Peer R.E. Mittl, Stjepan Jelakovic, Markus G. Grütter

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 559 KB

english, 2006

26

Stabilizing Ionic Interactions in a Full-consensus Ankyrin Repeat Protein

Tobias Merz, Svava K. Wetzel, Susan Firbank, Andreas Plückthun, Markus G. Grütter, Peer R.E. Mittl

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 799 KB

english, 2008

27

The Crystal Structure of Human Pyrin B30.2 Domain: Implications for Mutations Associated with Familial Mediterranean Fever

Christopher Weinert, Christian Grütter, Heidi Roschitzki-Voser, Peer R.E. Mittl, Markus G. Grütter

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 841 KB

english, 2009

28

Structural Determinants for Improved Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module

Michaela A. Kramer, Svava K. Wetzel, Andreas Plückthun, Peer R.E. Mittl, Markus G. Grütter

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.43 MB

english, 2010

29

Human caspases in vitro: Expression, purification and kinetic characterization

Heidi Roschitzki-Voser, Thilo Schroeder, Esther D. Lenherr, Franziska Frölich, Andreas Schweizer, Mrudula Donepudi, Rajkumar Ganesan, Peer R.E. Mittl, Antonio Baici, Markus G. Grütter

Journal:

Protein Expression and Purification

Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

30

Autoproteolytic and Catalytic Mechanisms for the β-Aminopeptidase BapA—A Member of the Ntn Hydrolase Family

Tobias Merz, Tobias Heck, Birgit Geueke, Peer R.E. Mittl, Christophe Briand, Dieter Seebach, Hans-Peter E. Kohler, Markus G. Grütter

Journal:

Year:

2012

Language:

english

File:

PDF, 1.63 MB

english, 2012

31

Specific Inhibition of Caspase-3 by a Competitive DARPin: Molecular Mimicry between Native and Designed Inhibitors

Schroeder, Thilo, Barandun, Jonas, Flütsch, Andreas, Briand, Christophe, Mittl, Peer R.E., Grütter, Markus G.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.91 MB

english, 2013

32

Precision is essential for efficient catalysis in an evolved Kemp eliminase

Blomberg, Rebecca, Kries, Hajo, Pinkas, Daniel M., Mittl, Peer R. E., Grütter, Markus G., Privett, Heidi K., Mayo, Stephen L., Hilvert, Donald

Journal:

Year:

2013

Language:

english

File:

PDF, 705 KB

english, 2013

33

Inhibition of Human Glutathione Reductase by 10-Arylisoalloxazines: Crystallographic, Kinetic, and Electrochemical Studies

Schönleben-Janas, Annette, Kirsch, Peer, Mittl, Peer R. E., Schirmer, R. Heiner, Krauth-Siegel, R. Luise

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 201 KB

english, 1996

34

Disulfide Formation and Stability of a Cysteine-Rich Repeat Protein from Helicobacter pylori †

Devi, V. Sathya, Sprecher, Christine Berger, Hunziker, Peter, Mittl, Peer R. E., Bosshard, Hans Rudolf, Jelesarov, Ilian

Journal:

Year:

2006

Language:

english

File:

PDF, 207 KB

english, 2006

35

Crystal structures of designed armadillo repeat proteins: Implications of construct design and crystallization conditions on overall structure

Reichen, Christian, Madhurantakam, Chaithanya, Plückthun, Andreas, Mittl, Peer R. E.

Journal:

Protein Science

Year:

2014

Language:

english

File:

PDF, 586 KB

english, 2014

36

Helicobacter pylori Evolution: Lineage- Specific Adaptations in Homologs of Eukaryotic Sel1-Like Genes

Ogura, Masako, Perez, J. Christian, Mittl, Peer R. E., Lee, Hae-Kyung, Dailide, Geidrius, Tan, Shumin, Ito, Yoshiyuki, Secka, Ousman, Dailidiene, Daiva, Putty, Kalyani, Berg, Douglas E., Kalia, Awdhes

Journal:

PLoS Computational Biology

Year:

2007

Language:

english

File:

PDF, 1.41 MB

english, 2007

37

Generation of fluorogen-activating designed ankyrin repeat proteins (FADAs) as versatile sensor tools

Schütz, Marco, Batyuk, Alexander, Klenk, Christoph, Kummer, Lutz, de Picciotto, Seymour, Gülbakan, Basri, Wu, Yufan, Newby, Gregory A., Zosel, Franziska, Schöppe, Jendrik, Sedlák, Erik, Mittl, Peer R.

Journal:

Journal of Molecular Biology

Year:

2016

Language:

english

File:

PDF, 1.18 MB

english, 2016

38

Structure and energetic contributions of a designed modular peptide-binding protein with picomolar affinity

Hansen, Simon, Tremmel, Dirk, Madhurantakam, Chaithanya, Reichen, Christian, Mittl, Peer R. E., Plückthun, Andreas

Journal:

Journal of the American Chemical Society

Year:

2016

Language:

english

File:

PDF, 5.21 MB

english, 2016

39

A Chemically Programmed Proximal Ligand Enhances the Catalytic Properties of a Heme Enzyme

Green, Anthony P., Hayashi, Takahiro, Mittl, Peer R. E., Hilvert, Donald

Journal:

Journal of the American Chemical Society

Year:

2016

Language:

english

File:

PDF, 906 KB

english, 2016

40

Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase

Obexer, Richard, Godina, Alexei, Garrabou, Xavier, Mittl, Peer R. E., Baker, David, Griffiths, Andrew D., Hilvert, Donald

Journal:

Nature Chemistry

Year:

2016

Language:

english

File:

PDF, 5.21 MB

english, 2016

41

Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition

Reichen, Christian, Hansen, Simon, Forzani, Cristina, Honegger, Annemarie, Fleishman, Sarel J., Zhou, Ting, Parmeggiani, Fabio, Ernst, Patrick, Madhurantakam, Chaithanya, Ewald, Christina, Mittl, Peer

Journal:

Journal of Molecular Biology

Year:

2016

Language:

english

File:

PDF, 2.11 MB

english, 2016

42

Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects

Reichen, Christian, Madhurantakam, Chaithanya, Hansen, Simon, Grütter, Markus G., Plückthun, Andreas, Mittl, Peer R. E.

Journal:

Acta Crystallographica Section D Structural Biology

Year:

2016

Language:

english

File:

PDF, 1.15 MB

english, 2016

43

Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomers

Weinert, Christopher, Morger, Damien, Djekic, Aleksandra, Grütter, Markus G., Mittl, Peer R. E.

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.43 MB

english, 2015

44

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

Afroz, Tariq, Hock, Eva-Maria, Ernst, Patrick, Foglieni, Chiara, Jambeau, Melanie, Gilhespy, Larissa A. B., Laferriere, Florent, Maniecka, Zuzanna, Plückthun, Andreas, Mittl, Peer, Paganetti, Paolo, A

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 4.69 MB

english, 2017

45

Structures of designed armadillo repeat proteins binding to peptides fused to globular domains

Hansen, Simon, Kiefer, Jonathan D., Madhurantakam, Chaithanya, Mittl, Peer R. E., Plückthun, Andreas

Journal:

Protein Science

Year:

2017

Language:

english

File:

PDF, 749 KB

english, 2017

46

Rigidly connected multispecific artificial binders with adjustable geometries

Wu, Yufan, Batyuk, Alexander, Honegger, Annemarie, Brandl, Fabian, Mittl, Peer R. E., Plückthun, Andreas

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 3.78 MB

english, 2017

47

Designed Armadillo repeat proteins serve as scaffolds for the rational assembly of peptide binders with picomolar affinities

Mittl, Peer, Hansen, Simon, Ernst, Patrick, Plückthun, Andreas

Journal:

Acta Crystallographica Section A Foundations and Advances

Year:

2015

File:

PDF, 51 KB

2015

48

Structural basis for the selective inhibition of c-Jun N-terminal kinase 1 determined by rigid DARPin-DARPin fusions

Wu, Yufan, Honegger, Annemarie, Batyuk, Alexander, Mittl, Peer R.E., Plückthun, Andreas

Journal:

Journal of Molecular Biology

Year:

2017

Language:

english

File:

PDF, 389 KB

english, 2017

49

A Non-Canonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold

Pott, Moritz, Hayashi, Takahiro, Mori, Takahiro, Mittl, Peer R. E., Green, Anthony P., Hilvert, Donald

Journal:

Journal of the American Chemical Society

Year:

2018

Language:

english

File:

PDF, 1001 KB

english, 2018

50

Robustness of Helicobacter pylori Infection Conferred by Context-Variable Redundancy among Cysteine-Rich Paralogs

Putty, Kalyani, Marcus, Sarah A., Mittl, Peer R. E., Bogadi, Lindsey E., Hunter, Allison M., Arur, Swathi, Berg, Douglas E., Sethu, Palaniappan, Kalia, Awdhesh, Cascales, Eric

Journal:

Year:

2013

Language:

english

File:

PDF, 2.24 MB

english, 2013

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